1,1 Carbonyldiimidazole (CDI): Advanced Coupling Agent for Organic Synthesis and Pharmaceutical Applications

All Categories

1 1 carbonyldiimidazole cdi

1,1 Carbonyldiimidazole (CDI) is a versatile chemical reagent widely used in organic synthesis and pharmaceutical manufacturing. This white crystalline solid serves as an efficient coupling agent for the formation of amides, esters, and other carbonyl-containing compounds. Its molecular structure consists of two imidazole rings connected by a carbonyl group, making it highly reactive and selective in various chemical transformations. CDI functions by activating carboxylic acids through the formation of reactive intermediates, facilitating subsequent reactions with nucleophiles like amines or alcohols. The reagent's popularity stems from its ability to produce high yields under mild conditions while generating relatively benign byproducts. In pharmaceutical applications, CDI plays a crucial role in peptide synthesis and the production of active pharmaceutical ingredients. Its technological features include excellent stability when stored properly, consistent reaction outcomes, and compatibility with various solvents. The compound's applications extend beyond pharmaceuticals into polymer chemistry, where it aids in the synthesis of polyurethanes and other specialty materials.

New Products

1,1 Carbonyldiimidazole (CDI) offers numerous advantages that make it an indispensable tool in chemical synthesis and manufacturing processes. First, its exceptional reactivity allows for efficient coupling reactions under mild conditions, reducing energy consumption and minimizing side reactions. The reagent demonstrates remarkable selectivity, ensuring high-quality product formation while maintaining cost-effectiveness in large-scale operations. Unlike alternative coupling agents, CDI produces water-soluble byproducts that are easily separated from the desired products, simplifying purification procedures. The compound's stability at room temperature when properly stored eliminates the need for special handling equipment or extreme storage conditions, reducing operational costs. In pharmaceutical manufacturing, CDI's clean reaction profile and minimal toxic byproducts align with green chemistry principles, making it environmentally responsible. The versatility of CDI extends to its compatibility with various functional groups, enabling diverse synthetic transformations in a single step. Its solid form facilitates precise measurements and handling, ensuring accurate stoichiometry in reactions. The reagent's effectiveness in both small-scale laboratory synthesis and industrial-scale production demonstrates its scalability. Additionally, CDI's role in peptide synthesis has revolutionized the production of complex pharmaceutical intermediates, offering improved yields and reduced processing steps compared to traditional methods. The compound's ability to activate carboxylic acids selectively makes it invaluable in the synthesis of specific target molecules while preserving other functional groups.

Latest News

Unlocking the Power of N,N′-Carbonyldiimidazole: A Game-Changer in Chemistry

15

Apr

Unlocking the Power of N,N′-Carbonyldiimidazole: A Game-Changer in Chemistry

View More
N,N′-Carbonyldiimidazole: A Comprehensive Guide for Chemists

15

Apr

N,N′-Carbonyldiimidazole: A Comprehensive Guide for Chemists

View More
EMC Curing Catalysts: The Science Behind Faster Curing Times

09

May

EMC Curing Catalysts: The Science Behind Faster Curing Times

View More
N,N′-Carbonyldiimidazole can improve thermal safety for electrolyte in lithium battery

09

May

N,N′-Carbonyldiimidazole can improve thermal safety for electrolyte in lithium battery

View More

Get a Free Quote

Our representative will contact you soon.
Email
Name
Company Name
Message
0/1000

1 1 carbonyldiimidazole cdi

Superior Coupling Efficiency

Superior Coupling Efficiency

1,1 Carbonyldiimidazole (CDI) demonstrates exceptional coupling efficiency in organic synthesis, particularly in forming amide and ester bonds. This remarkable feature stems from its unique molecular architecture, which enables rapid activation of carboxylic acids under mild conditions. The coupling process occurs through a well-defined mechanism, where CDI first reacts with the carboxylic acid to form a highly reactive intermediate. This intermediate then readily reacts with various nucleophiles, including amines and alcohols, to form the desired products with excellent yields. The efficiency is further enhanced by the reagent's ability to minimize side reactions, resulting in cleaner product profiles and reduced purification requirements. This superior coupling efficiency translates to significant time and resource savings in both research and industrial applications, making CDI an economically advantageous choice for synthetic chemists and process developers.
Environmental and Safety Benefits

Environmental and Safety Benefits

The environmental and safety profile of 1,1 Carbonyldiimidazole sets it apart from traditional coupling reagents. Unlike many alternatives that generate toxic or hazardous byproducts, CDI produces water-soluble imidazole as its primary byproduct, which is both environmentally benign and easily removed from reaction mixtures. This characteristic aligns perfectly with green chemistry principles and modern sustainability requirements in chemical manufacturing. The reagent's solid form at room temperature reduces exposure risks during handling and eliminates the need for specialized containment systems. Furthermore, its stability under normal storage conditions minimizes the risk of decomposition or dangerous side reactions, enhancing workplace safety. The clean reaction profile of CDI also reduces waste generation and the need for extensive purification procedures, contributing to a smaller environmental footprint in chemical processes.
Versatility in Applications

Versatility in Applications

The remarkable versatility of 1,1 Carbonyldiimidazole makes it an invaluable tool across multiple chemical disciplines. In pharmaceutical synthesis, it excels in peptide bond formation, enabling the creation of complex drug molecules with high precision. The reagent's compatibility with various functional groups allows for selective transformations without affecting other molecular features, making it ideal for multi-step syntheses. In polymer chemistry, CDI facilitates the production of specialty materials through controlled polymerization reactions. Its application extends to analytical chemistry, where it serves as a derivatizing agent for various analytical procedures. The reagent's effectiveness in both small-scale laboratory work and industrial-scale production demonstrates its scalability and adaptability to different operational requirements. This versatility reduces the need for multiple reagents in synthetic procedures, streamlining processes and inventory management.