Carbonyldiimidazole (CDI): Advanced Coupling Agent for Efficient Chemical Synthesis

All Categories

carbonyldiimidazole cdi

Carbonyldiimidazole (CDI) is a versatile chemical reagent that plays a crucial role in organic synthesis and pharmaceutical manufacturing. This powerful compound serves as an effective coupling agent, facilitating the formation of amides, esters, and other important chemical bonds. CDI's molecular structure consists of two imidazole rings connected by a carbonyl group, which enables its exceptional reactivity and versatility in various chemical transformations. In laboratory and industrial settings, CDI is particularly valued for its ability to activate carboxylic acids, forming reactive intermediates that readily react with nucleophiles to form new chemical bonds. This characteristic makes it an indispensable tool in peptide synthesis, polymer chemistry, and the development of pharmaceutical compounds. The reagent operates under mild conditions, producing relatively harmless byproducts, primarily imidazole and carbon dioxide, which can be easily removed from reaction mixtures. Additionally, CDI demonstrates remarkable stability when stored properly, making it a practical choice for both research and industrial applications. Its role in modern chemistry extends beyond traditional synthetic applications, finding use in the production of advanced materials, bioconjugates, and modified proteins.

Popular Products

The advantages of carbonyldiimidazole (CDI) make it a preferred choice in numerous chemical applications. First and foremost, CDI offers exceptional selectivity in chemical reactions, ensuring precise control over product formation and minimizing unwanted side reactions. This selectivity translates to higher yields and purer end products, reducing purification costs and time. The reagent's ability to function under mild conditions prevents the degradation of sensitive compounds, making it particularly valuable in the synthesis of complex molecules and biomolecules. Another significant advantage is CDI's environmental profile, as it produces biodegradable byproducts and requires less hazardous disposal procedures compared to alternative coupling agents. The compound's stability at room temperature, when properly stored, eliminates the need for specialized storage conditions and extends its shelf life, providing cost-effective benefits for laboratories and industrial facilities. In pharmaceutical manufacturing, CDI's versatility allows for the development of diverse chemical modifications and the creation of new drug candidates. Its role in peptide synthesis is particularly noteworthy, as it enables efficient amino acid coupling without racemization, maintaining the structural integrity of the final products. The reagent's compatibility with automated synthesis systems further enhances its utility in modern research and development settings. Additionally, CDI's solubility in various organic solvents provides flexibility in reaction design and optimization, while its controlled reactivity allows for precise manipulation of reaction conditions to achieve desired outcomes.

Practical Tips

EMC Curing Catalysts: The Future of High-Quality Production

15

Apr

EMC Curing Catalysts: The Future of High-Quality Production

View More
Unlocking the Power of N,N′-Carbonyldiimidazole: A Game-Changer in Chemistry

15

Apr

Unlocking the Power of N,N′-Carbonyldiimidazole: A Game-Changer in Chemistry

View More
High-efficient curing catalyst is critical to harmonizing for EMC melting flowability

09

May

High-efficient curing catalyst is critical to harmonizing for EMC melting flowability

View More
N,N′-Carbonyldiimidazole can improve thermal safety for electrolyte in lithium battery

09

May

N,N′-Carbonyldiimidazole can improve thermal safety for electrolyte in lithium battery

View More

Get a Free Quote

Our representative will contact you soon.
Email
Name
Company Name
Message
0/1000

carbonyldiimidazole cdi

Superior Coupling Efficiency

Superior Coupling Efficiency

Carbonyldiimidazole (CDI) demonstrates exceptional coupling efficiency in chemical synthesis, making it an invaluable tool for researchers and manufacturers. The reagent's unique molecular structure enables rapid activation of carboxylic acids, forming highly reactive intermediates that readily participate in subsequent reactions. This enhanced reactivity translates to faster reaction times and improved yields, significantly reducing production costs and resource consumption. The coupling process occurs with remarkable specificity, minimizing the formation of side products and simplifying downstream purification procedures. In peptide synthesis, this efficiency is particularly evident as CDI facilitates the formation of amide bonds without compromising the stereochemical integrity of amino acids. The reagent's ability to maintain consistent performance across various scales of operation, from laboratory experiments to industrial production, ensures reliable and reproducible results.
Versatile Application Range

Versatile Application Range

The versatility of carbonyldiimidazole (CDI) extends across numerous chemical applications, making it an essential reagent in modern synthesis. Its ability to activate various functional groups allows for the creation of diverse chemical bonds, including amides, esters, and carbonates. This flexibility enables its use in multiple industries, from pharmaceutical development to materials science. In polymer chemistry, CDI serves as an efficient cross-linking agent, facilitating the synthesis of complex macromolecular structures. The reagent's compatibility with both organic and aqueous conditions expands its utility in bioconjugation reactions, enabling the modification of proteins and other biomolecules. Its role in the production of advanced materials, such as functionalized surfaces and smart polymers, demonstrates its adaptability to emerging technological needs.
Environmental and Safety Benefits

Environmental and Safety Benefits

Carbonyldiimidazole (CDI) offers significant environmental and safety advantages compared to traditional coupling reagents. The formation of environmentally benign byproducts, primarily imidazole and carbon dioxide, reduces the environmental impact of chemical processes. These byproducts can be easily removed from reaction mixtures through simple workup procedures, minimizing waste generation and disposal costs. The reagent's stability at room temperature enhances laboratory safety by reducing the risks associated with handling reactive compounds. Its non-corrosive nature and relatively low toxicity profile make it safer for laboratory personnel to work with, while its controlled reactivity prevents unexpected exothermic reactions. The ability to conduct reactions under mild conditions not only preserves sensitive substrates but also reduces energy consumption and the need for specialized equipment, contributing to more sustainable chemical practices.